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Learn more about why GLP-1RAs are being monitored by the World Anti-Doping Agency at the 2026 Winter Olympics.

In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.420.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.460.84)

Understanding tolerance mechanisms and personalized dose optimization helps many patients restart momentum without switching medications

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