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Despite a substantial body of evidence implicating abnormalities in intracellular Ca 2+ dynamics in the pathophysiology of bipolar disorder, the specific Ca 2+ -signalling defects in the brain that underpin the characteristic manic and depressive behaviours remains unclear

169,174 Moreover, delayed absorption of the concomitant drug due to delayed gastric emptying can be minimized by administering the drug 1 h before GLP-1 RAs or a dual GLP-1/GIP RA administration

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