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Researchers, including Ania Jastreboff, MD, PhD, shared data from two of the trials, TRANSCEND-T2D-1 and TRIUMPH-1.
Initial treatment withacetazolamide was discontinued due to intolerance.Exenatide was subsequently initiated, leading to early improvement in headache frequency and diplopia, independent of weight loss
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Semaglutide increased MASH resolution without worsening fibrosis and significantly increased the proportion of individuals achieving 1-stage fibrosis improvement compared with placebo, with a clinically meaningful number needed to treat
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