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Discontinuation, weight regain and employer cost pressure drive demand

One study published in 2025 in Diabetologia looked at whether taking GLP-1 drugs were associated with worsening of retinopathy when patients had no or only mild nonproliferative diabetic retinopathy (NPDR) at initiation of treatment

Research-grade tirzepatide is the same molecular structure a 39-amino-acid synthetic peptide with dual GLP-1 and GIP receptor affinity supplied as lyophilized powder in vials rather than pre-filled injection pens

Key Takeaways Retatrutide is not approved anywhere

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