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Evolutionary Biology Upon nutrient ingestion enteroendocrine L-cells secrete GLP-1, which has a crucial role in glucose metabolism regulation via enhancing insulin secretion and inhibiting glucagon release

A recent meta-analysis including data from SURMOUNT-1, a trial conducted in individuals with obesity, confirmed the favorable effects of tirzepatide on dyslipidemia, finding a 16 and 13.7% change from baseline in triglycerides and very low-density lipoproteins with tirzepatide 15 mg vs

doi: 10.1038/nrdp.2018.14 135 CampbellJEDruckerDJ

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