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Epidemiological studies suggest a higher incidence of PD among individuals with T2DM, with growing evidence that diabetes may accelerate the onset and progression of motor and cognitive symptoms

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when tirzepatide is paired with the anti-myostatin agent apitegromab, sarcopenic risk is mitigated by nearly halving lean mass loss compared with dual-incretin monotherapy (14.6% vs

Medications from these distinct classes of pharmaceutical agents may be used as treatment by themselves (monotherapy) or in a combination of 2 or more drugs from multiple classes with different mechanisms of action

Obesity has further been associated with higher disease activity and reduced time to flare