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The research says there can be a big drop in total body weight loss

J Clin Invest 122: 388-402, 2012

In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials

Potential Interactions Between GLP-1 Drugs and Thyroid Conditions Understanding potential interactions between GLP-1 receptor agonists and thyroid conditions requires consideration of both pharmacological mechanisms and clinical monitoring implications

Oral GLP-1 therapies are frequently associated with gastrointestinal side effects, including nausea, diarrhea, constipation, and vomiting