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Instead, we used PPADS (100 M), which did not itself trigger Ca 2+ responses in GLUTag cells or ND neurons (for GLUTag cells mean SEM 340/380 ratio = 0.07 0.02, n = 54

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[DOI] [PubMed] [Google Scholar] [167].Hegedus L, Moses AC, Zdravkovic M, Le Thi T, Daniels GH, GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide, The Journal of clinical endocrinology and metabolism, 96 (2011) 853860

The mechanism of concern centers on how these appetite-suppressing and satiety-enhancing effects might inadvertently lead to reduced fluid consumption