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In several US community-based studies from 1990 to 2009, the age- and sex-adjusted standardized incidence was 0.80 and 1.53 for HFrEF and HFpEF, respectively [21]

doi: 10.1038/304368a0 18 DAlessioD

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For most local injection-site reactions redness, itching, or mild swelling that clears within a few days you can keep injecting on schedule

Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG, et al