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Extended-duration effects of GLP-1 RAs and multi-agonists on liver-associated outcomes involving cirrhosis development, HCC incidence, and death from hepatic causes are being elucidated through ongoing observational studies and long-term trial extensions [65-70]

While nausea and diarrhea seem to hog all the headlines, semaglutide burping is a common side effect that can be frustratingand frankly, embarrassingto deal with

For the secondary outcomes, the hazard ratios were below the null value for myocardial infarction, ischaemic stroke, cardiovascular mortality, heart failure, and all cause mortality, but with wide confidence intervals that included the null

Long-term administration of (Pro 3 )GIP to obese mice on an HFD was found to reduce body weight by about 8% compared to controls, without affecting food intake, and decrease casual blood glucose levels during the course of treatment and attenuated insulin levels during an oral glucose tolerance test [118]

The recommended maintenance (long-term) dosage for adults is 3 mg per day