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Although NLY01 was not associated with any improvement in motor or non-motor features of Parkinsons disease compared with placebo, subgroup analyses suggested a potential benefit in young participants with motor manifestations [274]

Beyond their metabolic benefits, GLP-1 RAs exhibit neuroprotective and psychotropic effects, potentially benefiting mental health conditions like depression and anxiety

Such factors further prevent or discourage low SES patients from accessing the limited supply of GLP-1 RAs

This combination may: Reduce appetite Improve insulin sensitivity Increase calorie burning Promote significant fat reduction That triple-action mechanism is what makes it different from current GLP-1 medications

Other post-hoc tests are indicated in the figure legends