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J Endocrinol (1995) 146(1):1839.10.1677/joe.0.1460183 42 EtheridgeSLSpencerGJHeathDJGeneverPG

Ania Jastreboff, MD, PhD, has co-authored numerous research studies on dual- and triple-receptor hormone agonists, including retatrutide

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In the Phase 2 obesity trial, retatrutide 12 mg produced approximately 24.2% mean weight loss at 48 weeks ( Jastreboff et al., NEJM 2023 ), and the Phase 2 type 2 diabetes trial showed strong HbA1c and weight reductions ( Rosenstock et al., Lancet 2023 )

Most patients begin noticing reduced hunger within the first two weeks, though the pace and magnitude of weight loss vary based on individual metabolism, starting dose, and genetic factors that influence how your body processes this medication