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HI-PEITHO is the first large RCT to demonstrate that catheter-directed fibrinolysis plus anticoagulation significantly reduces the composite of PE-related death, cardiorespiratory decompensation, or PE recurrence versus anticoagulation alone (RR 0.39

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Additionally, the physical act of subcutaneous injection, whilst typically well-tolerated, can occasionally cause localised discomfort that patients perceive more broadly

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