tirzepatide and retatrutide together vs. Switching from Tirzepatide to Retatrutide?

Apovian CM, Aronne L, Rubino D, Still C, Wyatt H, Burns C, et al

With these methods, assuming no difference in cardiovascular risk between tirzepatide and comparators, it was determined that 133 participants with MACE-4 would provide 90% power to exclude the upper limit of the 95% CI of 1.8 at two-sided alpha = 0.05

Severe, persistent abdominal pain (especially if radiating to the back), vomiting with inability to keep fluids down for more than 24 hours, or symptoms of gallstones (right upper abdominal pain, jaundice) require urgent medical assessment

Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal and human studies

Weight and body composition are the most straightforward indicators