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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments

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UChicago Medicine bariatric surgeon Vanessa Buie, MD, MBA, explains the benefits of surgery as a long-term alternative to taking GLP-1 medications

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