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Topical pain relievers, heat/cold therapy, physical activity, and stretching offer non-drug alternatives

Tirzepatide specifically, as a dual GLP-1/GIP agonist, showed more pronounced reductions in LDL, triglycerides, and total cholesterol compared to placebo and SGLT2 inhibitors in a different paper

In some cases, it may cause side effects such as gastrointestinal problems, numbness, or a fast heart rate

Similar microbial shifts have been reported in obese mice, wherein liraglutide decreased species within Firmicutes (e.g., Lachnospiraceae , Clostridiales ) and increased beneficial taxa like Verrucomicrobia and Oscillospiraceae (Madsen et al., 2019)