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The real-world discontinuation rate for GLP-1 class drugs is already 20-50% within the first year tolerability isnt a footnote, its one of the biggest drivers of whether a drug actually works in practice

These effects were often more noticeable when doses were increased

Testosterone declines too

Research sponsored by Novo Nordisk in patients with type 2 diabetes found that, together with diet and exercise, Ozempic led to an average weight loss of almost 10 pounds, while Rybelsus led to an average weight loss of over eight pounds

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