glp-1 agonist adverse effects Part 2 of a 3-Part Series; Medications for Weight Loss Updated Ranking and Side Effects

Whilst great advancements have been made over the last century with regard to understanding the regulation of metabolic homeostasis which has yielded new therapeutic options for diseases such as T2D, it is unlikely that highly desirable more efficacious treatments will be developed for metabolic disorders until the complex systemic regulation of metabolic homeostasis becomes more intricately understood

GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats

The transmission of the beneficial effect of GLP-1RAs through fecal microbiota transplantation confirmed that GLP-1RAs indeed changed the composition of the gut microbiota in obese mice (Sun et al., 2025)

Peng S, Xu J, Ruan W, Li S, Xiao F

The significant burden of CKD and CVD in type 1 diabetes populations highlights the need to identify novel therapies with the potential for heart and kidney protection