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As your body adjusts to the medication and weight loss slows, many people find their temperature sensitivity improves

Grover SA, Kaouache M, Rempel P, et al

If its real, says Pearce, its probably very very rare and very low risk. Nevertheless, Pearce suggests that American clinicians will likely continue to follow prescribing guidelines for medical-legal reasons, if nothing else. Fortunately only a tiny minority of people are affected by this warning

PMID: 34347962

To view the other articles in this section visit Keywords: arcuate, brain, body weight, diabetes, dorsal vagal complex, energy balance, food intake, glucose, glucose metabolism, GLP1, hypothalamus, NTS, obesity Abbreviations AGRP agoutirelated protein CRH/CRF corticotropin releasing hormone/corticotropin releasing factor GIP gastric inhibitory polypeptide/glucosedependent insulinotropic polypeptide GLP1 glucagonlikepeptide 1 KO knockout MC 4 receptor melanocortin 4 receptor mRNA messenger RNA NPY neuropeptide Y SDA subdiaphragmatic vagal deafferentation Sim1 singleminded 1 TRH thyrotropin releasing hormone 1