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Several potentially modifiable risk factors in midlife, particularly metabolic factors (diabetes mellitus, hypertension, obesity, and low HDL cholesterol), hearing loss, traumatic brain injury, and alcohol abuse, are associated with an increased risk of later-life dementia [150]

Strategies to mitigate muscle loss include: Prioritizing protein at each meal before other macronutrients Incorporating resistance training at least 23 times weekly Monitoring body composition, not just scale weight Working with your healthcare provider if side effects prevent adequate nutritionnever adjust medication doses on your own Contact your healthcare provider immediately if you experience: Severe or persistent nausea, vomiting, or abdominal pain Signs of dehydration (extreme thirst, dizziness, dark urine) Low blood sugar symptoms (if taking insulin or sulfonylureas) Inability to eat or drink for more than 24 hours Selecting appropriate protein sources is essential for patients on GLP-1 therapy, particularly given the reduced appetite and early satiety these medications produce