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Inhibiting GABA A receptors in the paraventricular nucleus of the hypothalamus (PVN), the control centre of the SNS, abolishes the enhancing effect on insulin secretion induced by OB GLP-1R

41 This finding was consistent with oral semaglutide, with mild-to-moderate gastrointestinal adverse events being the most commonly reported events in clinical trials

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While these emerging medications hold promise for advancements in obesity-related healthcare, there is limited knowledge to date on the effectiveness of these drugs among diverse populations, and to what extent these treatments are accessible to groups disproportionately affected by obesity

[Table 4] Table 4