glp 1 gip glucagon triple agonist New strategies for the treatment of obesity and metabolic dysfunctions The Effects of Dual GLP-1/GIP

Designed based on an in-depth understanding of incretin biology, tirzepatide can simultaneously activate GLP-1 and GIP receptors, thereby exerting synergistic effects that translate into superior outcomes in glycemic control, body weight management, and pancreatic -cell function preservation (19, 20)

Consequently, other strategies for oral administration have been tested and developed, including (but not limited to) coadministration with enzyme inhibitors, structural modifications [cyclization, PEGylation, fatty acid conjugates of polypeptides (lipidization), fusing therapeutic proteins to cobalamin (vitamin B 12 )], and the use of delivery carriers or absorption enhancers

Kinalp C, Kurultak I, Ceri M, Keskinel I

doi: 10.1152/ajpendo.1996.271.3.E458

Researchers should also review our guides on peptide shelf life and reconstituted peptide stability for compound-specific storage recommendations