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95 ( n = 224) included a cohort with more severe disease with 17% of patients affected by perianal involvement and 24% classified as having penetrating or fistulizing disease

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For example, there have been However, that same mechanism may also translate into a dampening of emotional highs and lows, which some patients may interpret as apathy or decreased libido

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Functional studies in rat models have demonstrated that injection of GLP-1 has a dose-dependent effect on reducing feeding behaviors [54, 55], providing evidence of its function as a satiety mediator
