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Mitter SK, Rao HV, Qi X, Cai J, Sugrue A, Dunn WA Jr, et al

Hepatic Steatosis : Recently, a sub-study of the phase 3 clinical trial SURPASS-3 showed that, among patients receiving metformin and/or SGLT2 inhibitors, the addition of tirzepatide (10 or 15 mg) as compared to insulin degludec was able to significantly reduce hepatic fat content (evaluated by magnetic resonance) after 52 weeks of treatment

Given that liraglutide and semaglutide comprised the majority of studies, the results are most applicable to these agents, although the pooled analysis incorporated data from the entire GLP-1 RA class

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