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We acknowledge that the intervention is complex, likely to require at least 10 years of intervention for the endpoint of cancer incidence, and would include behavioural strategies to supplement the chemoprevention during weight loss intervention and maintenance

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Although evidence on sex differences in semaglutides weight loss efficacy remains controversial, several hypotheses have been proposed to explain why females may experience greater weight reduction than males: Pharmacokinetic differences: females often exhibit higher plasma levels of GLP-1 RAs due to lower BW and slower drug clearance compared with males, resulting in increased exposure to the medication and potentially greater weight loss [5557]

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