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CYP2D6 The CYP2D6 enzyme is critically involved in the metabolism of approximately 20-25% of all developed drugs and more than 48 different clinical substrates (drugs) for this enzyme have been identified, which include -blockers, antidepressants, opioid analgesics, antiarrhythmics, and antipsychotics

Melson E, Alexander A, Miras D, Papamargaritis D