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The absolute oral bioavailability of dapagliflozin following the administration of a 10 mg dose is 78%

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It expands access to GLP-1s beyond those with clinical obesity recognizing their potential benefits beyond weight alone

In a repeated self-administration paradigm that used freely moving mice with jugular catheters, exendin-4 (10 g/kg, i.p.) pretreatment shifted the cocaine dose-response curve downward by decreasing the total number of infusions earned for various unit doses of cocaine, suggesting a decrease in the reinforcing efficacy of cocaine [116]
