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Providers do not need to be Medicare-enrolled to write the prescription

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Increased muscle mass may also enhance energy expenditure and redirect energy use toward muscle rather than fat storage.[22] In humans, elevated MSTN levels have been associated with obesity.[27] In mice, MSTN inhibition reduces white fat accumulation, improves lipid metabolism in diabetic models, and promotes browning of white fat.[28] As low muscle mass is a risk factor for insulin resistance and obesity,[29] increasing muscle via MSTN blockade may enhance insulin sensitivity, partly through irisin-driven crosstalk between muscle and fat.[30] Irisin is an exercise-induced adipomyokine, generated by cleavage of the transmembrane protein fibronectin type III domain-containing protein 5 predominantly in skeletal muscle and, to a lesser extent, in adipose tissue

This interval aligns with recommendations from the Bone Health and Osteoporosis Foundation (BHOF) and allows sufficient time to detect clinically meaningful changes in bone density while enabling timely intervention if significant loss is identified

Patients with type 2 diabetes, who were on regular visits with at least two clinical visits annually at Tangdu Hospital were identified for this study