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Some evidence suggests dual agonists might better preserve lean body mass during weight loss, though this remains under investigation

Clinically, PCOS patients exhibit reduced gut microbial -diversity, an elevated Bacteroidetes-to-Firmicutes ratio, and decreased abundance of beneficial bacteria such as Akkermansia muciniphila

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1 The approval of liraglutide, semaglutide, and tirzepatide for chronic weight management has significantly expanded their use