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Liraglutide, a human GLP-1 analogue, significantly improves beta cell function in subjects with type 2 diabetes

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Taking metformin with meals further reduces nausea and diarrhea

Bariatric surgery, though beneficial, is associated with complications, one of which is post-gastric bypass hypoglycemia (PGBH)

GLP-1RAs directly stimulate POMC/CART neurons and indirectly inhibit NPY and AgRP to increase measures of satiety and decrease hunger, resulting in reduced energy intake, thereby facilitating weight loss (Figure 6)
