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Unlike currently approved weight loss medications, retatrutide works as a triple agonist, meaning it targets three different hormone receptors: GIP, GLP-1, and glucagon receptors
In the Phase 2 trial, the cohorts that escalated to higher maintenance doses began at 2mg weekly and increased by 2mg every 4 weeks
6 The biological complexity of NSCLCincluding heterogeneous antigen expression, immunosuppressive TME, and T cell exhaustion mediated by inhibitory checkpoints such as PD-1collectively hinders durable therapeutic responses
