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Seek prompt GP or prescriber advice if you experience: Severe or worsening pain at the injection site that persists beyond 24-48 hours or intensifies rather than improving Signs of infection including increasing redness spreading beyond the immediate injection site, warmth, swelling, pus or discharge, or fever Significant bruising that is extensive, painful, or accompanied by a hard lump under the skin Allergic reaction symptoms such as widespread rash, hives, facial swelling, difficulty breathing, or rapid heartbeatthese require immediate medical attention via 999 or A&E Persistent lumps or hard areas at injection sites that don't resolve within a few weeks, which may indicate lipohypertrophy Numbness, tingling, or shooting pain radiating from the injection site, suggesting possible nerve irritation Recurrent severe pain with every injection despite proper technique, which may indicate an underlying issue Injection site reactions can include mild, self-limiting symptoms such as redness, itching, or tenderness

YasminARoychoudhurySSenguptaPAhmedARanjan MadhuNPaul ChoudhuryAet al

Author contributions GM had the idea for the article, GM, MP, MEG, SB, VG performed the literature search, GM, MEG, SB, VG drafted and critically revised the work, LB, AC, WY, PS critically revised the work

This is where bariatric surgery, such as gastric sleeve, gastric bypass, or lap band, can be beneficial

Reversal of obesity by targeted ablation of adipose tissue