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For pembrolizumab, a drug generating $25 billion annually with perhaps 75% of revenue in the U.S., even modest biosimilar market share at a 30% discount to the Keytruda list price yields multi-billion dollar potential revenue

However, most patients experience appetite suppression within 1-4 weeks, and weight loss starts after 4 weeks

There were statistically significant differences favoring darolutamide for measures of pain, well-being, and urinary symptoms, but the differences did not reach clinically meaningful levels

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