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Description
Secondary confirmatory endpoints: The number and incidence of adjudicated events of severe e hypoglycemia, as defined in 2013 by the American Diabetes Association
The study found that weight regain varied with follow-up, with participants experiencing weight regain at eight, 12, and 20 weeks after stopping the medication
per 45 CFR 46, analyses of secondary, de-identified data are not human subjects research and do not require consent
In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)
Simultaneously, the obesity rate among adolescents was 19.7%
