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Many people split their dose, applying half in the morning and half before bed

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This results in muscle weakness that fluctuates over time and worsens with sustained activity

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People familiar with basal insulins in T2D will be very familiar with such simple, but highly effective, dose titration algorithms (note: insulin glargine, which uses a simple dose titration algorithm, has amassed over $70 billion in sales because it personalises the dose like this