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Early responders achieved 27.7% mean weight loss at week 72 Average weight loss across all participants reached 21% with semaglutide 7.2 mg Higher-dose Wegovy outperformed semaglutide 2.4 mg (17.5%) 84% of total weight loss was attributed to fat mass reduction Abdominal visceral fat declined by more than 30% Muscle function was preserved despite significant weight loss Data reinforces higher-dose semaglutide's potential in next-generation obesity care ------------------------------------------------------------- Stay up to date with everything obesity through my newsletter

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Little Black Book, Tennis icon partners with Ro to talk openly about weight, health, and the role of GLP-1 treatment

However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk