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2023, September 5
Key Takeaways Retatrutide half-life is approximately 6 days per the NEJM Phase 2 trial (Jastreboff et al., 2023) -- the most precise, citation-backed figure available
Tirzepatide has shown similar results: in a phase 2 trial, up to 73.3% of participants at the highest dose achieved MASH resolution without worsening fibrosis at 52 weeks, compared to 13.2% on placebo
[DOI] [PubMed] [Google Scholar] 73.Guo Z., et al
MiR-155 induces inflammation in macrophage exosomes and impairs the function of endothelial progenitor cells, so its inhibition is associated with improved endothelial function [62]
