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123 Besides, synaptic plasticity-related proteins, including CREB, pCREB, brain-derived neurotrophic factor (BDNF), and activity-regulated cytoskeleton (Arc) proteins, are significantly reduced

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Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC, an absorption enhancer for RYBELSUS , and because there are alternative formulations of semaglutide that do not contain SNAC that can be used during lactation, advise patients that breastfeeding is not recommended during treatment with RYBELSUS Please click here for RYBELSUS Prescribing Information, including Boxed Warning

Expression of target genes was assayed by quantitative real-time/reverse transcription (qRT)-PCR using Bio-Rad iTaq SYBR Green Supermix