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2024;12:e1268

Furthermore, GLP-1RAs have been shown to attenuate microglial activation and improve memory-related behaviors.71 Moreover, GLP-1RAs have demonstrated considerable therapeutic promise in animal models of both PD and AD.427,428,429 The compound NLY01 is particularly effective at attenuating the activity of proinflammatory microglia and preventing the transformation of astrocytes to a reactive phenotype

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N Engl J Med 292(19):9859 Ghimire P, Dhamoon AS (2023) Ketoacidosis

The other loses a larger proportion of muscle along with fat