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& Possani, L

Internally, the models first extract a subset of CpGs relevant to DNAm surrogates for plasma proteins and smoking pack-years, followed by transformation through weighted linear combinations

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This was calculated from ~232 lb starting weight.** These results with Wegovy are all the more impactful and provocative given the superior weight loss benefits despite facing off against a placebo group that was supplemented with lifestyle change that included calorie restriction (500 kcal deficit a day), increased physical activity (150 minutes/week), and counseling to promote adherence

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