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Beyond absolute oxidative rate, mitochondrial resilience depends on spare respiratory capacitythe difference between basal and maximal electron transport fluxwhich reflects the ability to accommodate additional energetic demand without redox disequilibrium [64, 65]

doses of SAR441255 were studied in lean to overweight individuals and, at the two highest doses tested (80 and 150 ug), fasting blood glucose levels reached a nadir within the first hour [95]

Non-canonical activation mechanisms may exist and the ECD could play a different role assuming different conformations depending on the ligand 24

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