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Despite its oral advantage

The popularity of GLP-1 agonists to treat obesity has been skyrocketing in recent months, leading to both shortages and price increases

There are two types: active (soluble) analogs that can dissolve at a rate of 1 milligram per milliliter of water at pH 7.4, and inactive (insoluble) analogs that can dissolve at a rate of 0.5 milligrams per milliliter of water [3]

This requirement of ECL1 recognition drives the above six key positions in dual or triple agonists (tirzepatide, peptide 20 (MAR423), and retatrutide) to use amino acids similar to those in GLP-1/GCG, while the other positions in the middle region show considerable variability (Fig

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