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Studies addressing skeletal muscle quantity, quality, and functional capacity are needed to clarify the effects of GLP-1 RAs on sarcopenic obesity in older adults.

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The AUC of metformin was increased by 32% (90% confidence interval 1.231.43) by oral semaglutide coadministration versus metformin alone, whereas the Cmax was unaffected

Body aches during GLP-1 treatment can occur as an adjustment response, but individual variation is significant