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This reduction in basal metabolic rate means that the calorie deficit that initially led to weight loss becomes smaller over time, slowing further progress

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When weighed against the financial and health costs of weight regain, including renewed medication courses, worsening metabolic disease, and associated healthcare utilization, the maintenance approach frequently wins on pure economics

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The JPML found that NAION cases share common factual questions involving: Drug development and clinical testing Marketing and promotional practices Labeling and warning decisions Regulatory history and FDA interactions Scientific evidence linking GLP-1 drugs to optic nerve injury Because the medical mechanisms, risk profiles, and damages associated with permanent vision loss differ significantly from those of gastrointestinal claims, the court concluded that combining them would be inefficient and potentially unfair to plaintiffs

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