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Role of intra-islet paracrine signaling in the effects of pharmaceutical targeting of GLP-1 As current therapies focusing on increasing insulin sensitivity and/or insulin secretion fail to cure diabetes, one potentially underappreciated target for diabetes treatment is the alpha-cell

Although its not a complete list, the following types of medications can interact with Wegovy : Certain diabetes medications: Wegovy is more likely to have low blood glucose (sugar) levels if insulin, sulfonylureas, and meglitinides, also known as glinides, are taken together

When to seek urgent care: Severe or persistent nausea and vomiting leading to dehydration contact NHS 111 or your trial team Sudden, severe abdominal pain seek urgent medical attention Signs of a severe allergic reaction (anaphylaxis), including rash, swelling of the face, lips, or throat, or difficulty breathing call 999 immediately Upper right abdominal pain, fever, or jaundice seek medical attention Any new or worsening symptoms following an injection contact your trial team Reporting side effects: Patients and healthcare professionals are encouraged to report suspected adverse reactions via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk or via the Yellow Card app

A modest increase in resting heart rate was also observed in some participants receiving higher doses, which is an anticipated effect of glucagon receptor agonism and warrants ongoing monitoring in future trials