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Appetite decreases, portions naturally shrink, and early weight loss typically ranges from 3% to 5% of total body weight

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The triple receptor activity of retatrutide, targeting GLP-1, GIP, and glucagon receptors simultaneously, also contributes to sustained metabolic effects beyond what the half-life alone would predict

The researchers didnt compare the risk of milder problems like nausea and vomiting because people wouldnt necessarily report them to their doctors, Rodriguez said

Reduced appetite can also make it harder to fuel properly and get the right nutrients to support intense training, recovery and muscle maintenance