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SGLT2 inhibitors cause a carbohydrate deficit by glucosuria, which leads to an increased glucagon/insulin ratio, the metabolic shift from glucose to lipid utilization causing ketogenesis, and hence euglycemic DKA

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GLP-1 receptor agonists such as semaglutide are primarily designed for blood sugar control and weight management, but emerging research suggests indirect effects on stress hormone pathways

insurance), a limited evaluation of long-term costs associated with either treatment modality and their co-morbidities, and the reality of patient preference providing subjective value to either modality
