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In phase 3 adult clinical trials, most notably the SURMOUNT-1 study, tirzepatide produced significant and sustained reductions in body weight and metabolic parameters

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many, however, stringently captured HF events as secondary endpoints

We conclude by discussing existing gaps in the literature and proposing directions for future research

"Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11)"
