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GLP-1RA can also affect the process of skin aging through interaction with advanced glycation end products (AGEs) and RAGE (receptors of AGEs) activation
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On March 20, 2026, Chinas patent on semaglutide (the active ingredient in Ozempic and Wegovy) expiresyears ahead of patent expirations in the U.

Data are presented as medians (interquartile ranges) or frequencies (%), and Wilcoxon signed-rank tests and Mann-Whitney U tests were used for paired and nonpaired group comparisons, respectively
