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The variability in trial durations, ranging from 3 to 12 weeks across the included studies, and differences in the number of titration steps for each drug may further influence the reported incidence of gastrointestinal adverse events, particularly for agents like tirzepatide, where nausea risk escalates with higher doses (e.g., OR = 4.36, 95% CI: 3.425.61 at 10 mg) (Liu et al., 2025)

The affected communities in Japan now face the same challenges as those near U.S

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Benefits of GLP-1 RAs in addressing post-cessation weight gain One of the best ways to improve long-term health outcomes is to stop smoking, but many people are reluctant to do so because they worry about gaining weight later